Oncogenic Viruses and Their Molecular Diagnosis in Poultry

Oncogenic viruses: DUBbing their way to cancer

Ubiquitination is one of the most important post-translational modifications of proteins with a profound effect on their intracellular stability and activity. Deubiquitinases (DUBs), on the other hand, act by removing the ubiquitin moiety from proteins and thereby reverse their stability and/or activity. Besides, DUBs play a major role in maintenance of free ubiquitin pool, histone modification...

Oncogenic Viruses

Molecular Diagnosis of Plant Viruses

Makkouk, K.M. and S.G. Kumari. 2006. Molecular Diagnosis of Plant Viruses. Arab J. Pl. Prot. 24: 135-138. Proper virus identification is always the key in developing appropriate practical solutions to manage plant virus diseases. Recent advances in biotechnology and molecular biology have played a significant role in the development of rapid, specific and sensitive diagnostic tests. The use of ...

Molecular diagnosis of medical viruses.

The diagnosis of infectious diseases has been revolutionized by the development of molecular techniques, foremost with the applications of the polymerase chain reaction (PCR). The achievable high sensitivity and ease with which the method can be used to detect any known genetic sequence have led to its wide application in the life sciences. More recently, real-time PCR assays have provided addi...

Oncogenic viruses and hepatocellular carcinoma.

About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in ...